Anyone diagnosed with COVID-19 should immediately contact their primary care provider to inform them of the diagnosis, regardless of symptom severity or vaccination status. Access to additional treatment options, including monoclonal antibody infusion, may be available to prevent worsening symptoms or hospitalization. 

What is COVID-19 Monoclonal Antibody Infusion?

The monoclonal antibodies (mAb) used at St. Peter's Health were developed in 2020 to treat COVID-19 and were granted emergency use authorization by the Federal Food and Drug Administration (FDA). 

This medication is ONLY approved for outpatient use to treat or prevent the progression of COVID-19 disease in high-risk individuals who have tested positive for COVID-19. St. Peter's operates a COVID-19 monoclonal antibody treatment clinic at the Regional Medical Center. Provider referrals AND appointments are required

Who is eligible?

Only select high-risk people are eligible based on criteria outlined in the FDA's emergency use authorization (EUA) issued in November 2020. 

If you have tested positive for COVID-19, we encourage you to contact your provider to inform them of your diagnosis immediately. They will be able to discuss care and treatment options with you based on several factors. 

Patients who meet the following criteria MAY be eligible for monoclonal antibody treatment: 

  • A positive COVID-19 test; AND
  • Symptom onset of fewer than 10 days prior to appointment date; AND
  • 12 years of age or older weighting at least 40kg; AND
  • An eligible high-risk conditions/age as outlined in the emergency use authorization. The presence of a high-risk condition means that you may be eligible to receive the monoclonal antibody treatment under the EUA, but it doesn't mean you should receive the treatment. Clinical judgment is required, and availability is subject to local resources.

How to make an appointment?

Provider referrals are required for the COVID-19 Monoclonal Antibody Infusion Clinic at St. Peter's. Your provider will review whether you are eligible for the treatment and discuss the risks and benefits of the treatment before referring you for treatment. Please note that this is a two-hour appointment that requires a one-hour infusion. Once the referral is received, St. Peter’s will call you to schedule an appointment.

How does it work? Is it more effective than COVID-19 vaccination? 

COVID-19 vaccination is the best way to help prevent the acquisition of COVID-19, severe disease, hospitalization and death. Everyone who is eligible to receive the COVID-19 vaccine should get it as soon as possible. The vaccine is safe, effective, free and readily available. 

In clinical trials, monoclonal antibody therapy was shown to help reduce the progression of COVID-19 in high-risk individuals who have tested positive for COVID-19. Similar to the vaccine, there is a low incidence of adverse events associated with the therapy administration, including hypersensitivity, injection site reactions and infusion reactions. 

The COVID-19 virus attaches to the ACE-2 receptor on the surface of human cells and uses this protein for cellular entry. The virus achieves this using spike protein located on the surface. Both mAbs contained in the monoclonal antibody therapy bind to the spike protein on COVID-19, preventing attachment.


For referring providers only

Referring providers in St. Peter's five county services area (Lewis and Clark, Jefferson, Powell, Broadwater and Meagher counties) can find monoclonal antibody clinic documents here.

  • Regen-Cov Emergency Use Authorization
  • Regen-Cov infusion orders
  • Regen-Cov consent form
  • Regen-Cov fact sheet